Cholesterol balance is achieved both by synthesis in the body and by absorption in the gastrointestinal tract. Cholesterol synthesis and absorption are also critical determinants of plasma LDL cholesterol concentrations. In clinical practice, inhibitors of synthesis and inhibitors of absorption are both effective methods of lowering LDL cholesterol concentrations and may be utilized in combination. This review rationalizes these mechanisms of LDL reductions by placing them in the context of cholesterol balance as it is determined by digestive lipid metabolism. Cholesterol is an insoluble lipid molecule that plays a critical role in the structure and function of membrane bilayers.
Most cholesterol in the body is made in the liver and is necessary for good health. But some forms of cholesterol can cause several health issues, including damage to the liver. Cholesterol is a fatty molecule that is found in some foods as well as being made in the liver. There are two primary forms of cholesterol, one that is useful to the body, and one that can build up and cause health problems. HDL takes cholesterol from the cells in the body to the liver. The liver breaks it down or passes it out of the body as a waste product.
Cholesterol from the Ancient Greek chole- bile and stereos solid, followed by the chemical suffix -ol for an alcohol is an organic molecule. It is a sterol or modified steroid,  a type of lipid. Cholesterol also serves as a precursor for the biosynthesis of steroid hormones, bile acid  and vitamin D. Cholesterol is the principal sterol synthesized by all animals. In vertebrates, hepatic cells typically produce the greatest amounts.